Harnessing liver-resident memory T cells for protection against malaria

D Fernandez-Ruiz; MN de Menezes; LE Holz; S Ghilas; WR Heath; L Beattie

Journal article

Harnessing liver-resident memory T cells for protection against malaria

D Fernandez-Ruiz, MN de Menezes, LE Holz, S Ghilas, WR Heath, L Beattie

Expert Review of Vaccines | TAYLOR & FRANCIS LTD | Published : 2021

DOI: 10.1080/14760584.2021.1881485

Abstract

Introduction: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in peripheral organs. Harnessing TRM cells through vaccination hence promises unprecedented potential for protection against infection. A paramount example of this is malaria, a major infectious disease for which immunity through traditional vaccination strategies remains challenging. Liver TRM cells appear to be highly protective against malaria, and recent developments in our knowledge of the biology of these cells have defined promising, novel strategies for their induction. Areas covered: Here, we describe the path that led to the discovery of TRM cells and discuss..

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University of Melbourne Researchers

Lauren Holz Author

William Heath Author

Lynette Beattie Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

D Fernandez-Ruiz is supported by the National Health and Medical Research Council of Australia (NHMRC 1139486) and the CASS foundation (Medicine/Science grant). WR Heath is supported by NHMRC 1154457, 1113293, and 1124706, and by the Australian Research Council (CE140100011).